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Study of the human mitochondrial DNA polymorphism.
Author(s) -
Willis Catherine Mae,
Nikitin Alexey G.,
June Cindy
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a265-a
Subject(s) - haplogroup , mitochondrial dna , geography , population , ancient dna , human mitochondrial dna haplogroup , haplotype , european population , demography , evolutionary biology , biology , ethnology , genetics , history , genotype , sociology , gene
Traces of Paleolithic exodus routes of modern humans from Africa to Europe have been studied genetically using female specific ancestral lineages via mitochondrial DNA (mtDNA). We suggest modern humans entered Europe near the Carpathian Mountains and Hungarian Valley. If so, isolated populations of highlanders in Carpathian Europe may carry a genetic fingerprint of the ancient European predecessors and illustrate the migration routes of modern humans into Europe. Samples of Carpathian Highlander mtDNA was collected and haplotyped. The population of highlanders genetically resembles modern Europeans when analyzed by a hierarchical haplotyping scheme; however more studies need to be taken to fully understand the Carpathian Highlander's relation to the modern European population. Lineage‐specific polymorphic sites on mtDNA were analyzed in the Carpathian Highlander population. No difference in haplogroup distribution was found between Carpathian Highlanders and modern Europeans. Further analysis of European‐specific subhaplogroups in Carpathian Highlanders will further clarify the relationship between this group and the rest of European inhabitants.