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Study on Genetic and environmental factors determining QTc variation in Mongolian population.
Author(s) -
Im Sun Hwa,
Ju Youngseok,
Lee Mi Kyeong,
Jargal Ganchimeg,
Kim JongIl,
Sung John,
Cho Sungil,
Kim HyungLae,
Seo JeongSun
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a263-d
Subject(s) - qt interval , medicine , heritability , population , sudden cardiac death , qrs complex , genetic association , cardiology , biology , genetics , single nucleotide polymorphism , genotype , environmental health , gene
Several studies have reported a association between QTc interval prolongation and increased risk of sudden and non‐sudden cardiovascular mortality in both patients with cardiovascular disease and healthy individuals. QTc interval is a complex trait. Genes found for the long QT syndrome are unlikely to explain fully the QTc interval variation in the general population. And whole genome analysis about QTc interval variation is rare. We started a family study in Mongolia. In 2004, we visited a rural community in Selenge province, Mongolia, and gathered 1080 individuals from 142 families from there. In multivariable analysis, age, sex, heart rate, QRS duration and systolic BP showed association with QTc interval variation. We confirmed familial effect on QTc interval variation by familial correlation study and heritability was 0.32. And whole genome linkage analysis was carried out. In this anaysis, we found four peak determining QTc interval (maximum LOD score >1.5). Those regions were 7q21–36, 5q14–21, 4q22–31 and 2q13–14.