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Giant Cell Glioblastoma: Predictive and Prognostic Factors
Author(s) -
Maguire John Anthony,
Thiessen Brian,
Moore Wayne,
Miller Melinda,
Leung Esther,
Horsman Doug
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a26-b
Subject(s) - oligodendroglioma , giant cell , medicine , oligodendroglial tumor , pathology , immunohistochemistry , biopsy , glioma , biology , oncology , astrocytoma , cancer research
Objective: To evaluate predictive and prognostic factors in giant cell glioblastomas. Methods: WHO grade III astrocytomas with significant giant cell elements were studied in a tissue microarray (48 tumor biopsies from 37 individuals) by immunohistochemistry and FISH for 1p and 19q deletions using the VYSIS 1p/19q probe set. LOH 1p and 19q microsatellite analysis was also undertaken on 12/37. Survival, giant cell and oligodendroglioma component were evaluated. Results: Oligodendroglial elements, identified in all cases, were significant in 22/37 (59.5%). Of the 27/34 with poor (<12 months) or intermediate (1–2 years) survival, 3 had 19‐, 4 were polyploid, and 1 showed distal LOH 1p. In 1/7 showing better outcome (survival >2 years), small interstitial 1p deletions were found in 2 samples from the same case. Clear LOH 1p was not demonstrated in any case. Predominance of giant cell elements (5/7) and relatively distinct margins (2/7) were also associated with longer survival (>24 months). In 2/7, giant cell elements were identified after a diagnosis of oligodendroglioma in a previous biopsy. Conclusions : Giant cell glioblastoma comprises a heterogeneous group that encompasses high‐grade gliomas associated with very aggressive biologic behavior, to a smaller group associated with a better prognosis. The lack of significant chromosomal loss of 1p within the favorable group implicates other genetic variables.