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Panel review of a set of anaplastic oligodendroglioma of EORTC trial 26951: interobserver variation, correlation with 1p/19q loss and clinical outcome
Author(s) -
Kros Johan M.,
Gorlia Thierry,
Kouwenhoven Mathilde,
Collins Peter,
FigarellaBranger Dominique,
Giangaspero Felice,
Giannini Caterina,
Mohktari Kharima,
Mork Sverre J.,
Paetau Anders,
Reifenberger Guido,
Bent Martin J.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a26
Subject(s) - medicine , concordance , grading (engineering) , temozolomide , oncology , radiation therapy , correlation , pathology , gastroenterology , geometry , mathematics , civil engineering , engineering
In order to estimate consensus in typing and grading of oligodendroglial tumors (OD) and to correlate the consensus diagnosis with 1p/19q status and response to treatment, we performed a panel review (9 neuropathologists) of 114 patients included in EORTC trial 26951 (temozolomide / radiotherapy in AOD). The original diagnosis of AOD made in 90 (of 114) cases by the local pathologists (79%) was confirmed in 33% to 68% of cases (mean: 55%). The diagnosis of AOA made in 24 (of 114) cases by the local pathologists (21%) was confirmed in 7% to 34% (mean: 19%). Consensus on the diagnosis of AOD was reached in 84% of cases with high concordance (ICC 86%). The concordance was independent of the 1p/19q status. The survival curves for (consensus) OD, AOD, AOA and GBM ran separately in this consecutive order (AOA and GBM intertwined). The Kaplan‐Meyer curves for tumor grade, irrespective of tumor type, ran in the expected order and were significantly different from each other. Further, highest concordance was found for necrosis (ICC 92%) followed by endothelial abnormalities (ICC 87%), cell density (ICC 85%) and mitotic activity (ICC 85%). The absence of necrosis, the presence of endothelial proliferation and low cell density are correlated with better outcomes. In multivariate analysis, age and necrosis appeared to be independent prognostic factors.