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Association of the candidate genes on chromosome 7q with schizophrenia
Author(s) -
Kim Hyoun Geun,
Lee Seung Ku,
Kim Hyun Jae,
Cha YunYi,
Yun HongShik,
Kang HyunJun,
Kim Kyoung Yeon,
Yim Sung Vin,
Chung JooHo,
Kwack KyuBum
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a24-b
Subject(s) - single nucleotide polymorphism , candidate gene , schizophrenia (object oriented programming) , genetics , snp , haplotype , gene , genetic association , biology , bioinformatics , medicine , genotype , psychiatry
Schizophrenia is a psychiatric diagnosis that describes a mental disorder characterized by impairments in the perception or expression of reality and by significant social or occupational dysfunction, whose etiology involves interactions between both genetic and environmental vulnerability factor. SNP‐associated genes to be tested were selected from the PubMed and GeneCard and Harvard Institute of Proteomics databases by using data mining tool. Interestingly many genes were located on human chromosome 7q. One hundred and ninety two SNPs were selected from the candidate genes located on chromosome 7q by using bioinformatic tools and public SNP databases. Genomic DNAs were collected from venous blood from 170 controls and 298 Korean schizophrenia patients. Genotypes of the selected SNPs were determined using Illumina Sentix Array Matrix chip, and analyzed with Haploview, HapAnlyser, and SNPAlyze. We found that many candidate genes were non‐significantly associated with schizophrenia, even those were selected based on functional involvements. Very few genes were significantly associated with schizophrenia. In this study, we found schizophrenia associated genes and haplotype blocks by using Sentrix Array Matrix chips. Determination of causative SNPs and their functional role in the pathogenesis of schizophrenia is under way.