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Morphometric analysis of the recovering chick choroid following experimentally induced myopia
Author(s) -
Bratvold Jared M,
Carlson Edward C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a227-c
Subject(s) - choroid , medicine , ophthalmology , lymphatic system , stromal cell , fixation (population genetics) , refractive error , anatomy , retina , eye disease , biology , pathology , population , environmental health , neuroscience
Monocular translucent occluders (goggles) were used to induce form‐deprivation myopia for 14 days in young chicks followed by 3–14 days of recovery. Following perfusion and fixation in situ, LM digital analysis of intrachoroidal vascular and stromal compartmental areas were carried out using NIH Image. At 14 days of recovery, choroids from myopic eyes thickened significantly compared with contralateral controls. Choroids in contralateral control eyes also thickened significantly compared with ipislateral and contralateral eyes in non‐goggled control animals. At 3 days of myopia recovery, lymphatic vascular areas in myopia‐induced eyes increased 15.7% while stromal areas decreased by 12% compared with onset controls. However, at 14 days of recovery stromal areas increased 15.6% compared with onset controls. These results suggest that choroidal thickening during recovery from form‐deprivation myopia is mediated by fast acting lymphatic engorgement followed by stromal swelling. These events may be responsible for increased choroidal thickness during recovery from myopia and may act as a mechanism to immediately reduce refractive error by anterior displacement of the retina.