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Morphological sequelae of streptozotocin induced type 1 diabetes mellitus on components of the mitral valve apparatus
Author(s) -
Keane Aisling Lourda,
Wilkins Brendan
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a225-a
Subject(s) - diabetes mellitus , medicine , mitral valve , streptozotocin , cardiology , type 2 diabetes mellitus , mitral valve prolapse , endocrinology
Defects in the mitral valve account for up to 10% of all cardiovascular complications, however the prevalence of mitral valve prolapse may increase by up to 15% in individuals with type 1 diabetes. After three months of streptozotocin‐induced diabetes, the rat mitral valve showed an altered architecture in the valvular layers, loss of the fibrosa and elongated leaflets. At the base of the valve, cardiomyocytes showed widespread cardiomyolysis characterised by massive loss of myofilaments and mitochondria displayed swollen matrix chambers containing fragmented cristae. Also at the base of the valve, nerve bundles demonstrated characteristic features of diabetic autonomic neuropathy. Valvular endocardial endothelium (vEE) appeared to be completely distorted as the normally smooth appearance of the endothelial surface was deformed by the appearance of collagen type 1 bundles on the vEE monolayer. Valvular interstitial cells (VICs) also underwent considerable morphological change within the diabetic valve. In particular, VICs became lipid laden and developed several classical features of autophagy. This work shows that induced type 1 diabetes mellitus is associated with a diabetic valvulopathy. This research was funded by the National University of Ireland, Galway