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Phosphorylated tau accumulation in cortical and motor neurons in rats with high‐aluminum diet for more than two years after birth as well as over generations
Author(s) -
Oyanagi Kiyomitsu,
Hashimoto Tomoyo,
Kawakami Emiko,
Ogata Kentaro,
Takahama Sachiko,
Kihira Tameko,
Tsuji Sadatoshi,
Yasui Masayuki
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a22
Subject(s) - amyotrophic lateral sclerosis , substantia nigra , neuropathology , dopaminergic , medicine , endocrinology , biology , neuron , dopamine , neuroscience , disease
Objectives: For the elucidation of the pathogenesis of the parkinsonism‐dementia complex and amyotrophic lateral sclerosis of Guam, the present authors reported selective dopaminergic neuron loss in the substantia nigra in rats with low magnesium (Mg) diet over generations (Neuropathology, 2006). In the present study, phosphorylated (p)‐tau accumulation was examined in rats with high‐ aluminum (Al) diet over generations. Materials and methods: Wistar rats were domesticated with high‐Al diet for two generations. Tissue sampling was performed at embryonic day 16, postnatally 1 day, 1 month, 6 month, 1 year and 2 years and 4 months. Immunohistochemistry for p‐tau was performed for the specimen. Results: About half of the rats with high‐Al diet from birth till 2 years and 4 months old after birth and over two generations showed accumulation of p‐tau in cortical and brain stem motoneurons. Conclusion: The data of our previous and present studies, lead us to the conclusion that low‐Mg diet to rats over generations induces nigral neuron loss and high‐Al food, p‐tau accumulation in neurons.