Premium
Spindle morphogenesis and chromosome segregation, beyond the microtubule cytoskeleton
Author(s) -
Tsai MingYing,
Vong Queenie,
Zheng Yixian
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a210-d
Subject(s) - mitosis , microbiology and biotechnology , biology , chromosome segregation , morphogenesis , interphase , spindle apparatus , microtubule , spindle pole body , multipolar spindles , microtubule organizing center , cell cycle , cell division , lamin , cytoskeleton , genetics , chromosome , cell , centrosome , nucleus , gene
Spindle morphogenesis and chromosome segregation, beyond the microtubule cytoskeleton Accurate execution of mitosis is essential for equal chromosome segregation and for the maintenance of genome stability. Proper partitioning of other cellular structures and signaling molecules into daughter cells during mitosis is also important for cell fate determination and stem cell maintenance. Although cell cycle research in the past has shed light on the regulation of mitosis, our studies have revealed significant regulatory and morphological complexities of mitosis. Importantly, we have shown that regulation of mitosis involves cellular machineries that were previously thought to have functions only in interphase. I will describe two new pathways that coordinate with the cell cycle machinery to regulate mitotic spindle morphogenesis and chromosome segregation. I will also discuss how our studies of the new pathways have led us to define the role of nuclear lamin B in spindle morphogenesis.