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Developmental dynamics of mouse pelvis morphogenesis
Author(s) -
Pomikal Christine,
Streicher Johannes
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a204-b
Subject(s) - morphogenesis , appendicular skeleton , anatomy , pelvis , axial skeleton , skeleton (computer programming) , pelvic girdle , biology , process (computing) , computer science , biochemistry , operating system , gene
A key event in tetrapod evolution is the attachment of the appendicular skeleton to the body axis by the establishment of limb girdles. While the formal and molecular morphogenesis of either the axial or the limb skeleton have been extensively investigated in the past, their interconnection per se is still a blind spot. The present study investigates the early morphogenesis of the pelvic girdle in the mouse (Mus musculus f. domestica). Specimens from developmental stages Theiler 19 to Theiler 25 () were serially histologically sectioned and lightmicroscopically examined. From these serial histological sections computer‐based 3D‐models (2,3) were reconstructed. By subsequent 4D‐reconstruction the entire developmental dynamics of early pelvis morphogenesis were visualized and qualitatively and quantitatively analyzed. Our results verify, that in the mouse a single pelvic element originates from the appendicular skeleton, and secondarely attaches to the body axis. The disproportionate elongation of the iliac process briges the gap to and establishes the junction with the axial skeleton.