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Normal and Abnormal Kidney Development
Author(s) -
Hyink Deborah
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a2-c
Subject(s) - ureteric bud , mesenchyme , kidney development , nephron , kidney , renal dysplasia , organogenesis , morphogenesis , anatomy , agenesis , biology , mesonephric duct , hypoplasia , renal agenesis , hydronephrosis , pathology , microbiology and biotechnology , medicine , embryo , endocrinology , urinary system , embryonic stem cell , biochemistry , gene
Organogenesis of the kidney requires complex interactions between the epithelial ureteric bud, metanephric mesenchyme, vasculature, and nerves. Metanephric development begins when the ureteric bud grows into the metanephric mesenchyme and begins to branch. Nephrons are induced at the tips of the growing ureteric bud. Error in branching morphogenesis, nephron induction, cellular growth controls, and epithelial specification can lead to renal agenesis, hypoplasia, dysplasia, or cystic kidneys. This seminar examines the anatomy of the developing kidney, experimental approaches to study renal morphogenic mechanisms, and implications for human renal development.