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Treatment of metabolic syndrome with a whole‐grain enriched hypocaloric diet
Author(s) -
Katcher Heather Ilene,
Legro Richard S.,
KrisEtherton Penny M.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a176-e
Subject(s) - medicine , whole grains , waist , metabolic syndrome , blood pressure , weight loss , obesity , randomized controlled trial , phytoestrogens , endocrinology , food science , biology , estrogen
Whole grain foods are recommended in the dietary management of metabolic syndrome (MetS) because they contain many cardioprotective compounds including fiber, antioxidants, minerals, and phytoestrogens. We are completing a parallel‐arm study to evaluate the effects of whole grain foods on weight loss and cardiovascular disease (CVD) risk factors in MetS. Fifty obese men and women (25F, 25M) with MetS were randomized to receive dietary advice to either avoid whole grains or to have all of their grain servings each day (4–7 servings/d) from whole grains for 12 weeks. Participants in both groups were given the same dietary advice in all other respects to achieve weight loss. In a preliminary analysis of the first 34 participants, body weight decreased significantly from baseline in the whole grain and control groups (−3.3 ± 0.8kg and −4.8 ± 1.1kg, respectively; P<0.001). Overall, there were significant improvements in waist circumference, systolic and diastolic blood pressure, percent body fat by DXA, total and LDL cholesterol, and testosterone levels in males on both treatments. Analysis of changes in glucose tolerance, inflammation, and LDL particle size are in progress. We expect the results of this study will provide important information on the health benefits of a diet high in whole grains on metabolic syndrome and associated CVD risk. Support: General Mills Bell Institute and the GCRC, PSU (NIH grant M01RR10732)