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WISE‐2005: COMBINED AEROBIC AND RESISTIVE EXERCISE MAY HELP MITIGATE BONE LOSS DURING 60‐D SIMULATED MICROGRAVITY IN WOMEN
Author(s) -
Zwart Sara R,
Heer Martina,
Lee Stuart MC,
Macias Brandon,
Schneider Suzanne,
Trappe Scott,
Trappe Todd,
Hargens Alan,
Smith Scott M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a174-b
Subject(s) - aerobic exercise , medicine , supine position , bone resorption , bone remodeling , exercise physiology , physical therapy , endocrinology
Exercise can attenuate bone loss associated with disuse during bed rest (BR), an analog of space flight. Previous studies have examined the efficacy of aerobic or resistive exercise countermeasures, but not in combination. We sought to determine the effect of a concurrent resistive and aerobic exercise program on bone metabolism during BR. After a 20‐d ambulatory adaptation to confinement and diet, 16 women participated in a 60‐d head‐down‐tilt BR. Control subjects (CN, n=8) performed no countermeasures. Exercise subjects (EX, n=8) participated in exercise (6‐d·wk −1 ) alternating daily between supine treadmill exercise within lower body negative pressure (3–4 d·wk −1 ) and resistive fly‐wheel exercise (2–3 d·wk −1 ). In the last week of BR, bone resorption was greater (p < 0.05) than before BR in both groups. Helical peptide excretion increased in the CN (79 ± 44%, mean ± SD) and EX groups (64 ± 50%). N‐telopeptide also increased (CN: 51 ± 34%; EX: 43 ± 56%). However, bone‐specific alkaline phosphatase, a bone formation marker, tended to be higher in EX (26 ± 18%) than in CN (8 ± 33%) groups. The combination of resistive and aerobic exercise did not prevent bone resorption, but appeared to promote formation, potentially mitigating the net bone loss associated with simulated microgravity. This study was supported by CNES, CSA, ESA, NASA, and NASA grant NNJ04HF71G to ARH. MEDES (French Institute for Space Medicine and Physiology) organized the study.