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The effects of vitamin D receptor polymorphisms on bone mineral density in men and women
Author(s) -
Whitt Karen J,
Ling Shari M.,
Bos Angelo J. G.,
Muller Denis C.,
Roth Stephen M.,
Ferrucci Luigi
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a174
Subject(s) - medicine , femoral neck , bone mineral , calcitriol receptor , trochanter , osteoporosis , genotype , body mass index , greater trochanter , endocrinology , vitamin d and neurology , surgery , femur , biology , genetics , gene
The objective of this study was to evaluate differences in bone mineral density (BMD) according to vitamin D receptor (VDR) genotypes adjusting for age, gender, race, body mass index (BMI), and menopausal status in a sample of 840 age 19–93 female and male participants of the Baltimore Longitudinal Study of Aging. DNA samples were genotyped for VDR Fok1 and Bsm1 polymorphisms. Total body, trochanter, lumbar spine, and femoral neck BMD were evaluated by dual energy x‐ray absorptiometry (DXA). ANCOVA results demonstrated that the Bsm1 “bb” genotype was associated with significantly higher total body (p=.007) and trochanter (p=.002) BMD in Caucasian women. Fok1 and Bsm1 genotypes and BMD differed by menopausal status with the “FFBB” genotype combination associated with the lowest adjusted total body (p=.005), lumbar spine (p=.039), femoral neck (p=.005), and trochanter (p=.05) BMD in postmenopausal Caucasian women. The “FFBB” genotype combination was associated with lower adjusted mean lumbar spine BMD (p=.04) in Caucasian men. We conclude that VDR Bsm1 and Fok1 genotypes influence BMD in Caucasian women and men when adjusted for age, BMI, and menopausal status with the “B,” allele of the Bsm1 polymorphism associated with lower BMD. This research was supported in part by the Intramural Research Program of the NIH, NIA and an NINR Extramural grant.