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A combination nutritional therapy of psyllium (PSY) and plant sterols (PS) reduced plasma LDL‐C concentrations in hypercholesterolemic subjects by decreasing cholesteryl ester protein (CETP) activity and upregulating the LDL receptor
Author(s) -
Shrestha Sudeep,
Freake Hedley C,
McGrane Mary M,
Fernandez Maria Luz
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a156-b
Subject(s) - ldl receptor , chemistry , medicine , endocrinology , crossover study , cholesterol , cholesterylester transfer protein , placebo , pcsk9 , apolipoprotein b , receptor , ldl cholesterol , lipoprotein , alternative medicine , pathology
We previously demonstrated that a diet therapy involving consumption of 7.28 g PSY and 2 g of PS per day resulted in reductions in LDL‐C from 139.6 ± 27 to 119.8 ± 30.1 mg/dL (P < 0.01) in addition to decreases in the number of IDL particles and the smaller LDL subfractions in hypercholesterolemic individuals (n=33). The study design was a randomized double blind crossover in which the subjects consumed either 2 test cookies containing the PSY‐PS or 2 placebo cookies for 1 month. After a 3‐wk wash out period, they crossed over to the alternate treatment. Intake of the PSY‐PS cookie resulted in decrease in cholesterol concentration in LDL‐1 and LDL‐2 from 95.6 ± 25.5 and 24.6 ± 9.3 (mg/dL) to 88.2 ± 18 and 21 ± 10.3 (mg/dL) respectively (P<0.05). An increase in LDL peak size from 27.3 ± 0.77 to 27.5 ± 0.62 nm (P<0.05) and a decrease in LDL pattern B from 27% to 18 % (P<0.05) were also observed during the PSY‐PS period. CETP protein activity decreased 11% (P<0.05). Notably, the abundance of the LDL receptor in circulating mononuclear cells as measured by real time PCR was increased by 25% (P<0.03).These results indicate that the hypocholesterolemic action of PSY and PS can be explained by modifications in the intravascular processing of lipoproteins and by increasing LDL receptor‐mediated uptake.