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Boron deprivation increases plasma homocysteine, a factor negatively associated with bone composition and strength
Author(s) -
Nielsen Forrest H.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a125-b
Subject(s) - weanling , chemistry , medicine , endocrinology , fish oil , homocysteine , weaning , methionine , corn oil , linoleic acid , composition (language) , femur , metabolism , polyunsaturated fatty acid , biochemistry , fatty acid , amino acid , biology , food science , paleontology , linguistics , philosophy , fishery , fish <actinopterygii>
Boron (B) deprivation decreases trabecular bone in vertebrae of rats. Elevated plasma homocysteine (Hcy) has been associated with decreased trabecular bone. S‐adenosylmethionine, an intermediate in the formation of Hcy, has the highest known affinity for B of all mammalian biocompounds examined. Thus, the effect of B deprivation on plasma Hcy and cysteine (Cys) was determined. Because dietary n‐3 fatty acids affect the response to B deprivation and decrease plasma Hcy, an additional experimental variable was dietary oil. Female weanling rats were fed diets containing 75 g corn oil (CO)/kg and 0.1 (B‐def) or 3.1 (B‐adq) mg B/kg for 75 d then bred. After weaning, 30 male pups continued on the diets fed their mothers; another 30 male pups were fed diets containing 0.1 or 3.1mg B/kg and 65 g fish oil (FO)/kg and 10 g linoleic acid/kg. Plasma and femurs were collected at 18 wk. B‐def was confirmed by decreased femur B and B‐def responses of decreased femur iron and magnesium. B‐def increased plasma Hcy. Both B‐def and CO vs. FO increased plasma Cys. Thus, the B‐def rats fed CO had the highest plasma Cys. This group also had the lowest calcium and highest copper concentrations in the femur. The findings suggest that B and n‐3 fatty acids influence sulfur amino acid metabolism differently. Changing metabolic pathways involving cysteine may be partly responsible for the interaction between B and dietary oil affecting bone composition.