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Teeth Development and Alcoholism — Experimental Study
Author(s) -
Fonseca Ana G,
Gomes Pedro C,
Moreno Helena R,
Cabrita António M S
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a124-b
Subject(s) - odontoblast , ameloblast , enamel paint , dentistry , pregnancy , offspring , medicine , matrix (chemical analysis) , ethanol , dentin , chemistry , biology , biochemistry , chromatography , genetics
The connection between consumption of ethanol and pathology of development has been confirmed by several studies. This study was designed for the evaluation of the impact of maternal alcoholism on teeth development. Two groups of two pregnant Wistar female rats, 16 weeks old, were used. One group was maintained with no manipulation – group I. The other, group II, was submitted to the administration of 5% ethanol in the drinking water, during all the time of pregnancy. Fourteen of the rat's offspring of each group were used in this study. These were sacrificed on the 7th day of life and the hemimandibules were carefully removed. The following parameters were evaluated in the enamel organ: Thickness of ameloblast layer (TAM), thickness of the mineralized enamel matrix (TEM), thickness of mineralized dentine matrix (TDM), thickness of not mineralized Dentine matrix (TNDM) and thickness of odontoblast layer (TOL). In the group submitted to ethanol action during pregnancy there was significant differences of studied layers thickness. In the group I the thickness of TEM, TDM and TOL was larger than group II. The thickness of TNDM is similar in both groups. The thickness of TAM is smaller in group I than in group II. These results indicate that there are morphologic changes in the enamel organ of rats born from alcoholic mothers. Future studies are needed to determine if the effects are transitory or permanent.