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Dietary supplementation of phytase enhanced bone density in young pigs fed a high phosphorus diet
Author(s) -
Roy Prabir,
Lei Xin Gen
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a123-d
Subject(s) - phytase , bone ash , phosphorus , zoology , bone density , femur , chemistry , bone mineral , medicine , osteoporosis , endocrinology , biology , surgery , organic chemistry
Supplemental microbial phytase and strontium (Sr) have been shown to improve bone strength of pigs fed a high phosphorus (P) diets. The aim of the present study was to characterize the beneficial effect of phytase (OptiPhos, JBS United, Inc., Sheridan, IN) and Sr (SrCO3, Alfa Aesar, Ward Hill, MA) by mechanical, biochemical and radiology techniques. Ten pigs each (body weight = 7.60 ± 0.14 kg) were fed one of the four diets. Diet 1 was a corn‐soy basal diet (BD) + 0.25% inorganic P (iP) + 50 mg Sr/kg. Diet 2 was Diet 1 + 0.10% iP. Diet 3 was BD + 0.35% iP + 3,400 units of phytase/kg. Diet 4 was Diet 3 + 50 mg Sr/kg. After 8‐wk feeding, femur and metacarpal (n = 5) were collected to assay for mechanical traits and bone density based on radio opaqueness. While phytase (Diet 4 vs. Diet 2) improved (P < 0.01) 28% and 20% bone density respectively, of femurs and metacarpals, Sr (Diet 3 vs. Diet 4) improved that of femurs by 19% (P < 0.001). Phytase and Sr enhanced (P< 0.01) 8% femoral stiffness and 9% cortical thickness, respectively. Ash concentrations in cancellous bones of femurs and metacarpals were enhanced (P < 0.01) by 13% and 6%, respectively. In conclusion, the high level of phytase supplementation seemed to be more effective than the moderate level of Sr in improving bone density in young pigs fed the high phosphorus diet.