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Effects of Increased Dietary Dairy Calcium Combined with Caloric Restriction on Lipid Profile, LDL Particle Size and Apolipoproteins in Overweight/Obese Postmenopausal Women
Author(s) -
Fakhrawi Dina,
LammiKeefe Carol J,
Beeson Lawrence,
Darnell Allan,
CorderoMacIntyre Zaida
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a112-c
Subject(s) - medicine , endocrinology , chemistry , calcium , overweight , lipid profile , apolipoprotein b , cholesterol , zoology , obesity , biology
We evaluated the effects of low (LC, ~800 mg/d) and high (HC, ~1400 mg/d) dairy calcium on plasma lipid profile, LDL particle size and apolipoproteins (Apo B, CIII, E) in overweight/obese postmenopausal women (n = 56, average BMI of 33.1± 5.7kg/m 2 ). The 3‐mo. weight loss program involved caloric restriction (1,400 kcal/d) and 51% carbohydrate, 20.7 % protein, and 27.6 % fat. With 3 randomly selected days, average dairy calcium intake was: 832 mg/d, baseline, and at 3 months, LC, 861 ± 721 mg/d and HC, 1340 ± 494 mg/d (P < 0.05). For HC, plasma total cholesterol decreased: 218.6 ± 55.3 to 196.5 ± 45 mg/dL (P < 0.05), LDL cholesterol decreased: 129.2 ± 53.3 to 103.8 ± 42 mg/dL (P < 0.05), and HDL increased 59.2 ± 15.7 to 63 ± 12.2 mg/dL (P = 0.104). For LC, plasma total cholesterol did not change, LDL cholesterol decreased: 104 ± 35.9 to 93 ± 30 mg/dL (P < 0.05) and HDL increased 60.8 ± 15.9 to 64.8 ± 12.5 mg/dL (P = 0.098). Plasma TG, LDL particle size, mean, and pattern, and apolipoproteins Apo B, CIII, and E were not affected by this intervention in HC or LC. LDL peak size was decreased in LC (267 ± 11 to 263 ± 15 nm) and increased in HC (257 ± 9.4 to 259 ± 12.4 nm) with significance between groups (P < 0.05). We conclude from these data that dairy calcium combined with caloric restriction was effective in improving plasma lipids in this population of overweight/obese postmenopausal women. Supported by the Center for Health Research, Loma Linda University.