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The effect of different conjugated linoleic acid (CLA) isomers on fat distribution in women
Author(s) -
Raff Marianne,
Tholstrup Tine,
Toubro Søren,
Lund Pia,
Straarup Ellen Marie
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a111-b
Subject(s) - conjugated linoleic acid , insulin sensitivity , olive oil , chemistry , medicine , endocrinology , insulin , linoleic acid , abdominal fat , food science , insulin resistance , metabolism , fatty acid , zoology , biochemistry , body weight , biology
Background: CLA have been shown to reduce the fat mass (FM) in animals and in some, but not all, human studies. There are indications of differences in the effect on abdominal‐ and lower body FM and thereby also to insulin sensitivity. Objective: To investigate the effect of CLA isomers on fat distribution and insulin sensitivity. Design : 75 women were supplemented daily in 16 wk with 4.5 g of oil rich in cis 9 trans 11‐CLA, a mixture of predominantly cis 9 trans 11‐ & trans 10 cis 12‐CLA, or olive oil in a double‐blind, randomized, parallel intervention study. Before and at the end at of the intervention total and regional fat distribution were assessed by dual energy X‐ray absorptiometry and glucose metabolism by an oral glucose tolerance test (OGTT). Results: The CLA‐mixture reduced total FM by 4 % (1000 g) compared to olive oil (P=0.02), and also reduced lower‐body FM by 7 % (700 g) compared to olive oil (P=0.0008) and by 6 % (600 g) compared to cis 9, trans 11‐CLA (P=0.009). We found no differences in the treatment effects on insulin sensitivity and no correlations between FM and OGTT parameters. Conclusion : A CLA‐mixture may reduce lower‐, but not abdominal FM in women. However, we were not able to confirm any side effects on glucose metabolism. Sources of support: Danish Dairy Research Foundation and The Danish Research Development Program for Food Technology (Foetek).