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Synthesis, bio‐availability, and novel biological activities of safflomide and its analogues from safflower and coffee plants.
Author(s) -
Park Jae
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a111
Subject(s) - bioavailability , high performance liquid chromatography , human plasma , human health , chemistry , amide , chromatography , pharmacology , biology , biochemistry , medicine , environmental health
Safflomide (N‐caffeoyltryptamine) is a phenylpropanoid amide found in safflower and coffee plants. Recent studies indicate that safflomide may contain biological activities, implicated in preventing and/or treating human chronic diseases such as inflammation and atherosclerosis. However, only little is known about the effect of safflomide on the human diseases. Furthermore, bioavailability of the compound is nearly unknown, making it unable to accurately propose and/or assess its effects in humans. Therefore, in this study, safflomide and its analogues were synthesized chemically, and a high performance liquid chromatography (HPLC) method was developed using the synthesized safflomide as a standard. Using the developed HPLC method, the concentrations of safflomide in mouse plasma was measured following oral administrations. In this study, novel biological activities of safflomide and its analogues were also investigated related to human chronic diseases.