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Selenium status of a cohort of healthy Americans
Author(s) -
Combs Gerald F,
Watts Jennifer C,
Scheett Angela J,
Johnson LuAnn K,
Davis Cindy D,
Milner John A
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a105-a
Subject(s) - quartile , medicine , creatinine , cohort , selenium , urinary system , population , physiology , endocrinology , chemistry , confidence interval , environmental health , organic chemistry
Studies have indicated that few, if any, healthy Americans show signs of selenium (Se) deficiency; however, evidence exists that supplemental Se may reduce cancer risks at some sites in those of lower‐Se status. To determine the dose‐response relationship of Se intake and Se status in a healthy, non‐deficient population, we have undertaken a year‐long trial using nutritional supplements of Se (0, 50, 100 or 200 ug/day) in a group of 253 healthy Americans. At baseline this cohort showed plasma Se levels of 141.5±23.7 ng/ml, urinary Se of 58.2±21.5 ng Se/mg creatinine, and buccal cell Se of 10.2±6.5 ng Se/mg protein. Subjects were eligible if they used supplements providing ≤50 ug Se/day; those using such supplements had plasma Se levels (139.9±23.5 ng/ml, n=77) that were not different from those of non‐users (142.2±23.9 ng/ml, n=176, P=0.903). Plasma Se was not significantly associated with urinary Se, buccal Se, metabolic body size, age or gender. Subjects in the highest quartile of plasma Se level (>155 ng/ml) compared with those in the lowest quartile (<126 ng/ml) showed no differences in frequency of intake of foods likely to provide Se (wheat products, meats).