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Anthocyanins: Do they really prevent obesity?
Author(s) -
Prior Ronald L.,
Wu Xianli,
Hager Tiffany,
Hager Aaron,
Howard Luke
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a103-a
Subject(s) - obesity , medicine , endocrinology , berry , chemistry , body weight , composition (language) , zoology , food science , biology , botany , linguistics , philosophy
Male C57BL6 mice received diets with either 10% of cal. from fat (LF), a high fat diet [45% (HF45) or 60% (HF60) cal. from fat]. In 2 studies these were given with or without: freeze dried powders from whole blueberries (BB), strawberries (SB), black raspberries (BR) or concentrated anthocyanins (ACNs) from purple corn (PC) added to diet or SB or BB added to drinking water. Body composition was determined utilizing Echo MRI. Berries added to the LF diet did not alter wt. gain, final wts., body fat or protein (% BW), or diet or energy intake. However, in HF45 mice, wt. gain, final wts., body fat (%) and epididymal fat wts. increased and body protein decreased (p<0.01) compared to LF mice. In mice fed HF45 diet plus either BB or BR, body wt. gains, body fat (% of BW) and epididymal fat wts. were significantly greater than in the HF45 fed controls. Glucose tolerance decreased with age and in HF45 vs LF mice. SB or BB feeding did not alter glucose tolerance. Baseline plasma glucose was lower in SB vs HF45 fed mice. After 8 weeks mice fed the HF60 diet plus an extract of ACNs from BB in the water, had lower body wt. gains and body fat than the HF60 fed controls. Contrary to previously published reports ( J. Nutr . 133 :, 2003), ACNs from PC did not prevent obesity. ACNs when fed as part of the diet as the whole berry, did not prevent, and to the contrary, may have increased obesity. (Funded by NW Center for Small Fruits Res.)