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No impact of ghrelin on adaptive hyperphagia in short bowel syndrome
Author(s) -
Compher Charlene W,
Kinosian Bruce P,
Metz David C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a100-c
Subject(s) - ghrelin , peptide yy , medicine , endocrinology , growth hormone receptor , short bowel syndrome , chemistry , parenteral nutrition , hormone , neuropeptide y receptor , receptor , growth hormone , neuropeptide
Adaptive hyperphagia (AH) is associated with reduced dependence on parenteral nutrition (PN) in patients with short bowel syndrome (SBS), but mechanisms have not been described. Ghrelin (GHR) has orexigenic effects, while peptide YY (PYY) reduces intake. We evaluated whether GHR or PYY were related to caloric intake or absorption in patients with SBS. Patients were admitted twice for nutrient balance. Fasting plasma PYY and GHR were assayed in duplicate with Linco ELISA kits. Energy intake > 40 kcal/kg/d was AH. The median age was 62 (range 45–66) y, time with SBS 6.6 (range 2–29) y and BMI 21.2 (range 19 – 27.7 kg/m 2 ). Five patients had AH, 4 infused PN kcal. Neither GHR nor PYY was significantly related to energy intake or absorption (GHR: R=0.22 and R = −0.233, PYY: R=0.10 and R= −0.13 for PYY) or BMI (GHR: R= −0.540 (p=0.211), PYY: R= −0.12). GHR and PYY were not different by presence of AH or PN dependence. The rigorous AH seen in these patients with SBS was not related to fasting GHR or PYY, suggesting the need to explore other mechanisms. Supported in part by R03 DK062841‐01and by the PHS Research Grant M01 RR00040 from NIH.