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The role of CGPR ‐ receptor antagonist in the plastic process on the hepatopathies with toxical genesis
Author(s) -
Ponomarev Vladimir,
Lunegov Alexander,
Andreeva Nadezhda,
Kovalev Sergey
Publication year - 2022
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2022.36.s1.r3071
Subject(s) - connective tissue , pathology , bile duct , medicine , antagonist , receptor
Many research results showed that the CGPR concentration in the blood plasma has significantly increased by hepatopathies with different genesis. The hyperkinetic portal blood flow has caused this. This research's primary hypothesis was the potentiation of CGPR ‐ receptor antagonist to the liver's plastic process by toxical hepatopathies provocation. The study aimed to evaluate the influence of combination the hepatoprotective agent “Hepaton‐vet” (dose ‐0.5 mg/kg per rat during 7th days) and monoclonal antibodies G2 (IgG2, dose ‐0.75 ml/kg per rat one‐time before experimental start) on the hepatopathy's regenerative process which was 1,2‐dichloroethane induced during 7th days with following orthothanasia (the method by Malcom A., Steele M.D., 1991). White outbred rats were used (n=20). The body mass of rats was ranged from 180 to 220g. The liver histological examinations were performed by a visual method using Image J Software. Thus, the histologic pattern of rats' liver was included in the connective tissue membrane, which was obduced the liver externally. The hepatic lobules of rats have had shapes of hexagon prism without clean‐cut peripheries. The interlobular tissue in the lobule's feather included the interlobular vena, the interlobular artery, and the bile duct lined with cuboidal epithelium. The lobular base was sited central vein with hepatic plates, which were formed hepatocytes. The rats' hepatocytes had a wrong multiangular shape were was 60 % of all in the liver cells pattern was typical for liver with high regenerative level without signs of vassal‐ mesenchymal reactions, which was correlated with CGPR ‐ receptor antagonist. So, we can assume that the CGPR ‐ receptor antagonist drugs have a great variety in their administration, including the potentiation of other drugs used in the pharmacorrection of different pathologies. The balanced influence on the CGPR – receptors significantly influence the homeostasis maintenance and the nociception of the hepatobiliary system.