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Remote injury responses during zebrafish heart regeneration
Author(s) -
Poss Kenneth,
Sun Fei
Publication year - 2022
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2022.36.s1.0i676
Subject(s) - zebrafish , regeneration (biology) , biology , gene , medicine , microbiology and biotechnology , neuroscience , genetics
Acute trauma stimulates local repair but can also affect structures distant from the injury, for instance through the activity of circulating factors. To study the responses of remote tissues to injury and regeneration, we generated genome‐wide profiles from zebrafish brains following experimental cardiac damage. Our findings indicate regulatory mechanisms that distinguish short‐ and long‐range gene expression responses to injury.