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The phase of fat: Mechanisms and physiology of lipid storage
Author(s) -
Farese Robert V.,
Walther Tobias C.
Publication year - 2022
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2022.36.s1.0i217
Subject(s) - lipid droplet , organelle , lipid metabolism , chemistry , biochemistry , cytosol , triglyceride , microbiology and biotechnology , biophysics , enzyme , biology , cholesterol
The synthesis and storage of neutral lipids, such as triglycerides, are crucial for both cellular and physiological energy homeostasis. When fuels are abundant, triglycerides are synthesized in the ER by DGAT enzymes and subsequently stored in cytosolic organelles called lipid droplets. In the Farese & Walther laboratory, we study the molecular processes that govern the synthesis of energy storage lipids as well as their storage in and mobilization from lipid droplets. We will discuss our studies on genetic factors controlling triglyceride synthesis, lipid droplet formation and growth, lipid droplet protein targeting, and relevant aspects of the physiology of lipid storage and lipid excess.