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Moderators for the association between genotypes of the HTR1A ‐rs6295 or HTR2A ‐rs6311 polymorphisms and efficacy of SSRI treatment among the patients of Malay ethnic group
Author(s) -
Badamasi Ibrahim,
Lye Munn Sann,
Ibrahim Normala,
Ling King Hwa,
Abdul Razaq Nurul Asyikin,
Stanslas Johnson
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.05251
Subject(s) - malay , major depressive disorder , personality , genotyping , clinical psychology , psychology , big five personality traits , medicine , association (psychology) , genotype , psychiatry , biology , genetics , mood , social psychology , philosophy , linguistics , psychotherapist , gene
Background Major depressive disorder (MDD) has high level of morbidity. It shows great inter‐individual difference in treatment responses and a complete absence of reliable biomarkers. Hypothesis The evaluations between genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 with clinical treatment efficacy response (CTER) based on clinical and sociodemographic features can unravel a significant association result. Aim To identify moderators for the association between CTER with genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 in a population of Malay MDD patients. Objectives 1. To determine the association between genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 with CTER when patients are categorized based on their history of chronic disease and family history of psychiatric illness 2. To determine the association between genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 with CTER when patients are categorized based on the presence or absence of a number of personality trait types. 3. To determine the association between genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 with CTER when patients are categorized based on key socio‐demographic features. Methodology Ethical approval from appropriate authorities (NMRR‐14‐688‐19696) and informed consent from the MDD patients were obtained before recruitment. Patient were recruited over 2 years and provided blood for genotyping of the HTR1A‐ rs6295 and HTR2A‐ rs6311. Clinical features, socio‐demography, responses to Montogemery Asberg depression rating scale‐self (MADRS‐S) and Temperament /Personality questionnaires were obtained. Appropriate statistics for the association of the genotypes and CTER based on individual socio‐demographic and clinical features was done. Result The 142 patients were Muslims (100%), young (median age = 31.50 years), females (67.6%) and low income earners (62.7%). Patients carrying the CG+GG genotype of the HTR1A‐ rs6295 who have effectiveness (not the self‐criticism traits) had significantly lower odd (P = 0.016, OR = 0.099 (0.011 – 0.860)) for clinical treatment efficacy response (CTER). A Similar result in patients carrying the GG genotype of the HTR1A‐ rs6295 polymorphism who do not have anxious‐worrying, social avoidance, inter‐personal sensitivity, effectiveness, cooperativeness, perfectionism and irritability. Unmarried patients with the GG ‐ HTR1A ‐rs6295 genotype have a significantly lower odd P = 0.029 (OR = 0.126 (CI = 0.015 ‐1.058)) for CTER . Low income earners who have the CC ‐ HTR1A ‐rs6295 have higher odd for CTER. Failure of CTER was significantly more among patients who have no history of any chronic disease and possess the HTR1A‐ rs6295 ‐GG or HTR2A‐ rs6311 ‐GA genotypes. Conclusion The association of the genotypes of HTR1A ‐rs6295 or HTR2A ‐rs6311 polymorphism with CTER was observed in patients who were married, of low income earning, diagnosed with a chronic disease and have some key personality traits with the exception of effectiveness trait.