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The Role of Adrenergic Receptors, Muscarinic Receptors, Glucocorticoids, Reactive Oxygen Species in Stress‐Induced Cardiac Injury
Author(s) -
Naryzhnaya Natalia,
Kurbatov Boris,
Prokudina Ekaterina,
Maslov Leonid,
Gorbunov Alexander,
Mukhomedzyanov Alexander,
Krylatov Andrey,
Voronkov Nikita,
Sementsov Andrey,
Saushkin Viktor
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.05067
Subject(s) - medicine , endocrinology , receptor , angiotensin ii , mineralocorticoid receptor , chemistry
Takotsubo syndrome (TS) is a rare but dangerous disease that can be fatal. The pathogenesis of TS is not well understood because there is no animal model of TS that would be as close as possible to TS. We hypothesized that adrenergic receptors, muscarinic receptors, glucocorticoids, reactive oxygen species (ROS) can be involved in the development of stress‐induced cardiac injury (SICI). It was established that immobilization of rats induced the state which is similar TS in human: increased 99m Tc‐pyrophosphate ( 99m Tc‐PP) accumulation in the heart, QTc interval prolongation, contractility dysfunction of the heart, elevation of the serum creatine kinase MB level. Immobilization stress induced an increase in coronary blood flow. Blockade of β 1 ‐adrenergic receptor (AR) prevents 99m Tc‐PP accumulation in the myocardium. Blockade of β 2 ‐AR aggravates SICI. Stimulation of β 2 ‐AR increased cardiac tolerance to stress. Inhibition of β 3 ‐AR, α 1 ‐AR, mineralocorticoid receptor and angiotensin AT 1 receptor had no effect on SICI. Blockade of peripheral muscarinic receptors or α 2 ‐AR aggravates SICI. Inhibition of glucocorticoid receptor attenuated but not abolished SICI. Pretreatment with the selective β 1 ‐AR antagonist atenolol attenuates stress‐induced cardiac contractility dysfunction but not recover cardiac contractility completely. It was established that ROS are not involved in SICI. It was obtained indirect evidence that circulated in blood catecholamines play an important role in SICI. Consequently, the activation of β 1 ‐AR plays an important role in SICI. However, there are other receptors which are also involved in SICI.