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Blood parameters and reproductive function of highly productive cows using an organic immunomodulatory drug
Author(s) -
Baimishev Murat,
Eremin Sergey,
Baimishev Hamidulla,
Plymyashov Kirill,
Nikitin Georgy,
Baimishev Rinat
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.04994
Subject(s) - ice calving , globulin , lactation , zoology , chemistry , medicine , endocrinology , biology , pregnancy , genetics
The aim of the study was to correct the morphofunctional status of highly productive cows before calving by using an organic immunomodulatory drug. Four groups of Holstein cows (production > 8500 kg per lactation) were formed (n=10 in each group). The immunomodulatory drug contains formic aldehyde 0.07‐0.24%, sodium chlorine 0.90‐0.95, distilled water. The drug was injected intramuscularly at 25‐30 days before calving with an interval of 7 days, three times and 8‐10 hours after calving, once (experimental group‐1 – 4.0 ml, experimental group‐2 ‐ 6.0 ml, experimental group‐3 ‐ 8.0 ml). The 4th group was a control. Blood samples were taken 25‐30 days before calving, 5 days before calving and 5 days after parturition. Using an immunomodulatory drug in a dose of 6.0 ml 5 days before calving, changes occur in the blood of the animal. In the blood serum of cows, the increased level of Ca by 0.5 mmol/l, P – by 0.22 mmol/l, alkaline reserve – by 4.03 vol%CO2, glucose – by 0.80 mmol/l, total protein – by 9.01 g/l, alpha‐globulins – by 2.98%, Ig A – by 36.9%, Ig M – by 15.73%, Ig G – by 50.02%, reduced ratio of AlT and AsT enzymes by 17.04 and 15.74 units./l (up to the reference level), beta‐globulins – by 3.44%. This contributed to a reduction in complications of calving and postpartum period by 40.0%, uterine involution by 19.04 days compared to a dose of 4 ml. The difference in criteria that characterize the morphofunctional state when using 8 ml and 6 ml is insignificant. Results of the research are statistically significant (P<0.01). Using an immunomodulatory drug in a dose of 6 ml, the cellular composition, morphobiochemical parameters of the blood are improved. The appearance of obstetric and gynecological pathologies is reduced by 40%, the retention of plaсеnta by 30%, the duration of uterine involution by 19.04 days, the period of effective insemination by 33.56 days. The fertilization of cows in the first hunt is increased by 30% than in the control group.