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Detection of atrazine metabolites in blood serum and liver of mice exposed via their waters to 0, 3 and 30 ppb atrazine.
Author(s) -
Gaalswyk McKenna
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.04857
Subject(s) - atrazine , metabolite , environmental chemistry , chemistry , toxicology , pesticide , biology , biochemistry , agronomy
Atrazine, which is an herbicide used on crops throughout the Midwest, is present in drinking water due to its ability to be carried in runoff from fields. While levels of less than 3 ppb in drinking water is deemed as safe by the USDA, atrazine is often found at much higher levels in nature due to the widespread use of this chemical on fields. Recent studies have identified that atrazine decreases Glutathione‐S‐transferase (GST) gene hepatic expression when mice are exposed to atrazine in their drinking water. This study investigated if there was a build up of atrazine metabolites in the serum and liver of exposed mice and correlate the species of metabolite amount to the effect it has on gene expression of GST.