Premium
Bisphenol Z and its analogs alter meiosis in C. elegans
Author(s) -
Kuzmanov Aleksandra,
Roberts Andrew,
Bowen John,
Zhou Xinrui,
Timmons Shan
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.04122
Subject(s) - bisphenol a , bisphenol s , bisphenol , meiosis , brood , apoptosis , biology , germline , human health , hormesis , benzhydryl compounds , chemistry , andrology , toxicology , microbiology and biotechnology , genetics , endocrinology , zoology , medicine , gene , oxidative stress , organic chemistry , environmental health , epoxy
Bisphenol A (BPA), a synthetic plasticizer, has been repeatedly linked to reproductive disorders. Because of growing human health concerns, manufacturers started seeking alternatives, which resulted in the replacement of BPA with other bisphenols, such as bisphenol S (BPS) and bisphenol Z (BPZ). Whereas numerous studies suggest that BPS may be as toxic as BPA, the impact of BPZ is less understood. To investigate the effect of BPZ on the reproductive health, we used a nematode C. elegans. Previous studies in this model organism have showed that BPA and BPS prevent timely meiotic double‐strand break repair and result in increased apoptosis of the germline nuclei. The worms exposed to BPZ and its three novel analogs appear to be affected in a similar fashion. All four chemicals caused a marked reduction in the brood size compared to the wild type worms. In addition, the number of apoptotic nuclei was significantly increased by the exposure to all evaluated bisphenols. Our preliminary findings suggest that BPZ as well as its analogs alter meiosis in C. elegans resulting in diminished reproductive capacity.