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Phenotypic Motor Impulsivity is Dynamically Altered Following Oxycodone Self‐Administration in Male Rats
Author(s) -
Smith Ashley,
Campbell Veronica,
Chapman Holly,
Stutz Sonja,
Fox Robert,
Moeller F. Gerard,
Cunningham Kathryn,
Anastasio Noelle
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.03889
Subject(s) - oxycodone , impulsivity , self administration , abstinence , psychology , opioid , medicine , addiction , extinction (optical mineralogy) , stimulant , pharmacology , neuroscience , developmental psychology , psychiatry , receptor , biology , paleontology
Aim : Relapse is a dynamic, essential barrier to recovery in substance use disorders. Relapse is often precipitated by exposure to drug‐associated cues and has been tied to impulsive behavior, particularly in stimulant use disorders, although this relationship is less clear in opioid use disorder (OUD). Motor impulsivity is characterized by impulsive action or the inability to withhold a premature response. Here, we tested the hypothesis that phenotypic levels of motor impulsivity may predict drug‐seeking behavior during abstinence from oxycodone self‐administration. Methods : Naïve male Sprague‐Dawley rats (n=56) were trained to stability on the 1‐choice serial time reaction (1‐CSRT) task and phenotyped as high impulsive (HI) or low impulsive (LI). Rats were then trained to self‐administer (SA) oxycodone (0.1 mg/kg/inf) until stability on a fixed ratio 5 schedule of reinforcement, followed by reinitiation of stable 1‐CSRT performance. On the day corresponding to 30 days after the last oxycodone SA session, rats underwent a drug‐seeking test session in which lever presses were reinforced with the discrete cue complex previously paired with oxycodone infusion. Results : Acquisition of oxycodone SA and the cumulative levels of drug intake observed did not differ in HI vs. LI rats. Interestingly, HI and LI rats failed to exhibit their original phenotype following termination of oxycodone SA, with HI rats exhibiting decreased, and LI rats exhibiting increased, premature responses relative to baseline. Cue‐reinforced lever presses did not differ in HI vs. LI rats. Conclusion : These data suggest that antecedent levels of motor impulsivity were not a major driver of oxycodone intake under the present conditions, but that the motor impulsivity endophenotype is dynamically altered following oxycodone SA without impacting oxycodone‐seeking. These results indicate, for the first time, that abstinence from oxycodone alters levels of motor impulsivity, and underscore the importance of motor impulsivity as a factor contributing to the cyclical nature of OUD.