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Hyperoxia Exaggerates Systolic Blood Pressure Response in Patients with Peripheral Arterial Disease
Author(s) -
Gao Zhaohui,
Stavres Jonathon,
Cui Jian,
Brandt Kristen,
Kim Dani JinKwang,
Blaha Cheryl,
Cauffman Aimee,
Luck Jonathan,
Sinoway Lawrence
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.03596
Subject(s) - hyperoxia , medicine , blood pressure , cardiology , heart rate , hemodynamics , mean arterial pressure , anesthesia , lung
It is well known that acute oxidative stress evokes different effects in patients with atherosclerotic disease and in normal subjects. The effects of acute hyperoxia, an important acute oxidative stressor, on hemodynamics have not been well studied in patients with peripheral arterial disease (PAD). We recruited 20 PAD patients (14M, 6F, 66 ± 6yrs), and 16 age‐matched control subjects (10M, 6F, 65 ± 8yrs). The ankle‐brachial pressure index (ABI) in the most affected limbs of the patients was 0.58 ± 0.15, compared to 1.04 ± 0.09 in the controls. Blood pressure and ECG were monitored at baseline and during hyperoxia (100% oxygen for 5 mins, as an acute oxidative stress test). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), and rate‐pressure product (RPP) were averaged across the final minute of baseline and hyperoxia, and were compared across time and between groups using Repeated Measures Analyses of Variance (RMANOVA). Results indicated a significant interaction for SBP (F 1,1 =4.65, P =0.04), which was explained by a significant increase in SBP from baseline to hyperoxia in the PAD group (126 ± 13 mmHg vs. 137 ± 16 mmHg, respectively, P <0.001) that was not observed in the control group (115 ± 9 mmHg vs. 120 ± 7 mmHg at baseline and hyperoxia, respectively, P =0.06). In contrast, no significant interactions were observed for DBP ( P =0.43), MBP ( P =0.47), HR ( P =0.71), or RPP ( P =0.11). Considering 53% of PAD patients were on antihypertensive medicine, whereas none of the control subjects were on chronic antihypertensive agents, the likely effects of hyperoxia on systolic pressure may have been underestimated in our study.