Premium
Protective effect of Helix Aspersa muller snail secretion filtrate in a mouse model of excisional wound
Author(s) -
Gugliandolo Enrico,
Interdonato Livia,
Licata Patrizia,
Crupi Rosalia,
Cuzzocrea Salvatore
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.03433
The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix aspersa muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of excisional wound repair, which has been widely used to test the drugs efficacies. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of snail secretion filtrate, suggesting its possible useful use in the treatment or skin diseases.