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Impact of JUULing (JUUL e‐cigarette) on Central Hemodynamics and Arterial Stiffness
Author(s) -
Franzen Klaas,
Gernun Solveig,
Benthien Julia,
Mallock Nadja,
Rüther Tobias,
Drömann Daniel,
Rabenstein Andrea
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.03137
Subject(s) - arterial stiffness , blood pressure , pulse wave velocity , medicine , cardiology , hemodynamics , peripheral , pulse pressure , heart rate , nicotine
Growing e‐cigarette market, impact of JUUL e‐cigarettes on youth as well as the vaping‐associated lung injury (VALI) led to much discussion on the potential benefits and risks of pods, JUUL devices, and conventional e‐cigarettes compared with combustible cigarettes. Independent data are required assessing the effects of these products on cardiovascular surrogate parameters and cardiovascular risk. Therefore, we conducted a study addressing the effects on arterial stiffness of different nicotine delivery devices compared to combustible cigarettes. Methods We recruited for the first study 32 participants (15 active smokers and 17 active vapers) performing a total of 39 measurements before and 5, 15, and 30 minutes after participants smoked a combustible cigarette or vaped a JUUL e‐cigarette. Measurements included peripheral and central blood pressures and parameters of arterial stiffness using a Mobil‐O‐Graph (IEM, Germany). Results Within the study we show an significant increase of peripheral systolic blood pressure, central blood pressure, and peripheral pulse in all three groups (each P < 0.05). Heart rate (HR) changes lasted significantly longer than blood pressure changes. In additions the augmentation index and pulse wave velocity increased in all three groups, and a multivariate analysis of variance showed that the increases were independent of systolic blood pressure, sex, age, device, and HR. Conclusion In conclusion, changes in blood pressure and arterial stiffness are similar after smoking and JUULing. These changes may be associated with an increased cardiovascular risk compared with no product use. However, a long‐term follow‐up evaluation of JUULing and a head‐to‐head comparison with conventional e‐cigarettes as well as heated tobacco products are still needed.