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Traditional Central and Peripheral Physiologic Adaptations not Required to Improve Fatigability and Recovery in Response to a Vigorous Aerobic Exercise Regimen
Author(s) -
Wooten Liana,
Neville Brian,
Keyser Randall,
Guccione Andrew
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.00151
Subject(s) - medicine , cardiology , aerobic exercise , vo2 max , respiratory exchange ratio , regimen , stroke volume , cycling , physical therapy , heart rate , zoology , blood pressure , biology , archaeology , history
Purpose : This study assessed relationships between cardiovascular (CV) function, oxygen extraction, respiratory buffering, performance fatigability, and recovery capacity in response to chronic exercise perturbation. Methods : 16 healthy men (n=6, age=39.5±14.3) and women (n=10, age=50.0±11.7) completed peak cardiopulmonary exercise testing (CPET) followed by 10 minutes of passive recovery before and after a vigorous, 4‐week aerobic exercise cycling training regimen. Primary measures of interest include CV function (cardiac output: Q, stroke volume: SV), oxygen extraction (arteriovenous oxygen difference: a‐vO 2 diff), respiratory buffering (excess VCO 2 ), performance fatigability (pk‐Time), and recovery (VO 2 oxidative response index/ORI). Data were analyzed for significant (p<0.05) changes using paired t‐tests and associations between variables were assessed using correlations (r 2 ). Results : Significant increases in excess VCO 2 (0.58L, p=0.003) and pk‐Time (66sec, p<0.001), as well as improvements in recovery (VO 2 ‐off ORI 8.7ml/s, p=0.001) were found following training. No significant increases were found in Q (0.413 l/min, p=0.827), SV (3.07 ml; p=0.717) or a‐vO 2 diff (7.41 l/min, p=0.420). Q was significantly associated with pk‐Time (r 2 =0.433, p=0.013) and VO 2 ‐off ORI (r 2 =0.506, p=0.003) and excess VCO 2 was significantly associated with pk‐Time (r 2 =0.848, p<0.001) and VO 2 ‐off ORI (r 2 =0.819, p<0.001), while a‐vO 2 difference was not significantly correlated with any of these measures. Conclusion : In the current study, measures of performance fatigability and recovery changed significantly, while measures of cardiac function and oxygen extraction did not significantly improve, in response to a 4‐week, high‐intensity cycling protocol. Furthermore, measures of respiratory buffering both increased following training and demonstrated strong relationships with performance fatigability and recovery. These findings suggest that traditional central and peripheral adaptations may not be required to decrease performance fatigability and improve recovery indicators, while non‐traditional measures of respiratory buffering may play a vital role, recognizing that such adaptations and relationships may be protocol dependent.