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Analysis of risk factors for carotid plaque instability in patients with coronary heart disease
Author(s) -
Hao Chunyan,
Duan Hubin,
Bai Sha,
Wang Suping
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.00146
Subject(s) - medicine , cardiology , uric acid , homocysteine , coronary artery disease , artery , carotid arteries
Objective To study the risk factors influencing the characteristics of carotid artery plaque in patients with coronary heart disease (CHD). Methods Data of patients admitted to our hospital from March 2018 to August 2019 who were diagnosed with coronary artery disease by coronary angiography were collected. A total of 127 patients with cervical vascular plaques were detected by carotid artery color Doppler ultrasonography. According to the morphology and acoustic characteristics of the plaques, they were divided into the unstable plaque group (78 cases) and the stable plaque group (49 cases). The general data and blood indicators of the two groups were compared, including blood lipid level, fasting blood glucose, uric acid and homocysteine, etc. Meanwhile, the correlation degree between the characteristics of carotid artery plaque and risk factors was evaluated, so as to analyze the influence of the above hematological indicators on the characteristics of carotid artery plaque in patients with coronary heart disease combined with carotid artery plaque. Results Among the 127 patients, the serum uric acid and homocysteine levels in the carotid artery unstable plaque group were higher than those in the stable plaque group ( p < 0.05), and there was a correlation between serum uric acid and plaque instability (OR=1.020, p < 0.05), indicating that high uric acid level increased the risk of unstable plaque in patients with coronary heart disease. Conclusion The elevated serum uric acid level in CHD population is closely related to the instability of carotid plaque. The instability of carotid plaque can be used as one of the indicators to predict and evaluate the severity of coronary heart disease.