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The Piwi‐piRNA Pathway: a New Paradigm in Gene Regulation
Author(s) -
Lin Haifan
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2021.35.s1.00032
Subject(s) - piwi interacting rna , rasirna , pseudogene , biology , transposable element , genetics , gene , argonaute , rna , genome , computational biology , small rna , germline , rna interference
Small non‐coding RNAs have been recognized as key players in gene regulation. In 2006, we and others independently discovered a novel class of small RNAs named Piwi‐interacting RNAs (piRNAs) that interact with Piwi proteins in the germline of diverse organisms. PiRNAs are mostly 26‐32 nucleotide in length and correspond to all types of genomic sequences, represent a distinct small‐RNA pathway. In my talk, I will report our recent progress that reveal the crucial roles of the Piwi‐piRNA pathway in mediating the regulation of mRNA, lncRNA, and satellite RNA homeostasis by transposons and pseudogenes, which represent a new paradigm of regulation that connect all major constituents of the genome.