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The Efficacy of Cola acuminata on Gram‐Negative Bacteria
Author(s) -
Telles Caroline,
McKinsey Cayla
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.09893
Subject(s) - antimicrobial , enterobacter aerogenes , nut , staphylococcus aureus , klebsiella pneumoniae , bacteria , microbiology and biotechnology , enterobacter , traditional medicine , gram negative bacteria , klebsiella , biology , food science , escherichia coli , medicine , biochemistry , genetics , structural engineering , gene , engineering
Traditional healers have long used plant‐derived products to prevent or cure infectious diseases. The main reason is that these natural products may contain antimicrobial agents that are effective against drug‐resistant bacteria. The Bizzy nut is a “cure‐all” herbal medicine that is useful for many medical purposes, such as removal of poisons from the body; birth control; control of diabetes; weight loss; and contains antimicrobial activity. Previously, we reported on the antimicrobial property of the natural product, Bizzy nut, in gram‐positive bacteria. In this study, we extended this analysis to gram‐negative organisms. The antimicrobial activity of an acetone extract (Biz‐3) of Bizzy nut was determined using the agar well diffusion method and the MIC assay. We observed that a concentration between 30ug/mL to 50ug/mL Bizzy nut was effective in killing gram‐negative organisms. Our data demonstrate that gram‐positive organisms, such as Staphylococcus aureus , was 5–6‐times more potent towards the Bizzy nut extract. The order of potency of the organisms examined is Klebsiella pneumoniae > Escherichia coli > Enterobacter aerogenes . This study suggests that Bizzy nut contains selective antimicrobial activity.