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Toll‐Like Receptor Expression in the Hypothalamus of Rats Subjected to Chronic Inflammatory Pain Model
Author(s) -
Teel Austin,
Winter Lori,
Duric Vanja,
Clayton Sarah C.
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.09626
Subject(s) - medicine , chronic pain , inflammation , hypothalamus , blood pressure , proinflammatory cytokine , diabetes mellitus , endocrinology , physical therapy
Hypertension is the state of having an abnormally and chronically elevated blood pressure. There are many comorbidities of hypertension, which includes cardiovascular disease, stroke, kidney disease, diabetes mellitus, and psychological disorders, such as chronic pain. Clinical observations suggest that approximately 39% of individuals experiencing chronic pain also have hypertension. While inflammation has been documented in areas of the brain in hypertension and chronic pain, the influence of chronic pain on activation of proinflammatory mechanisms within the cardioregulatory nuclei in the brain has not been evaluated. We speculate that chronic pain leads to inflammation in cardioregulatory brain regions, such as the hypothalamus and brainstem, that leads to dysregulation of autonomic tone and increases in blood pressure. Therefore, in the current study, we evaluated mRNA expression of different members of the Toll‐Like Receptors (TLR) family and associated proteins in the hypothalamus of rats exposed to 21 days of chronic inflammatory pain [i.e., 3 weekly injections of Complete Freund’s Adjuvant (CFA) into the hind paw]. Preliminary results show a decrease in the hypothalamic expression of TLR3 and an increase in the expression of TLR5, TLR7, and TRAM as a result of the pain protocol. These data suggest a relationship between chronic pain and hypothalamic inflammation and may suggest a possible target for probing the intersection of chronic pain and the development of hypertension. Support or Funding Information DMU IOER and MSBS program