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Cardioprotective Effects of Melatonin, Berberine and Curcumin by Inducing the JAK2/STAT3 Signaling Pathway in Myocardial Ischemia Repercussion
Author(s) -
Khan Naushad,
Pandey Rajeev,
Murthy Guru
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.09485
Subject(s) - cardioprotection , berberine , curcumin , medicine , melatonin , ischemia , reperfusion injury , pharmacology , cardiology , myocardial ischemia
Ischemic heart disease and stroke are the World’s major cause of deaths, accounting for a combined 15.2 million deaths in 2016 as per WHO. Following Cardiac Ischemia, we are often faced with a bigger problem of damage induced by myocardial ischemia/reperfusion injury. It has been observed that reperfused myocardium displays more severe injury than myocardium subjected to the same ischemic duration that had not been reperfused. This observation has led to deduce that reperfusion could result in Myocardial injury more severe than one that could have occurred by Ischemia alone. However certain mediators like melatonin, berberine and curcumin have shown to induce JAK2/STAT3 signaling pathway and have shown a protective effect against myocardial ischemia reperfusion. In the present work we will be mainly focusing on the correlation between Melatonin, Berberine & Curcumin and cardiac JAK2/STAT3 receptors in cardioprotection against myocardial ischemic reperfusion. Support or Funding Information Community Health and Research Center of Spartan (CHARCOS), Spartan Health Sciences University, School of Medicine, St. Lucia