Premium
Hosta longipes and its Active Compounds Control Melanogenesis in B16F10 Melanoma Cells
Author(s) -
Sohn Eun-Hwa,
Kim Sung Hyeok,
Ha Chang Woo,
Lee Jinwoo,
Kim Youngseok,
Chae Doobyeong,
Sung Sikwon,
Ham Jungyeob,
Kim Su-Nam
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.09403
Subject(s) - linoleic acid , christian ministry , chemistry , biology , botany , fatty acid , biochemistry , philosophy , theology
Hosta longipes (FR. et SAV.) MATSUMURA ( Liliaceae ) is an edible vegetable in Korea and widely distributed throughout Korea, China, and Japan. It is called “Bi‐Bi‐Chu” in Korea, and its young leaves are consumed raw as a salad. This plant has been used as a Korean traditional medicine for the treatment of swelling, inflammation and snake bites. In this study, we confirmed the whitening effects of Hosta longipes ethanol extract in B16F10 cells and identified that hexane fraction had the highest whitening effect by serial solvent fractionation. To identify the active ingredients in the hexane fraction we performed column chromatography and it was confirmed that linolenic acid and linoleic acid reduced the melanin contents in B16F10 cells. The anti‐melanogenesis potential of linolenic acid and linoleic acid in Hosta longipes will provide insight into the development of new skin whitening products. Support or Funding Information This research was financially supported by the Ministry of Small and Medium‐sized Enterprises(SMEs) and Startups(MSS), Korea, under the “Regional Star‐Enterprise Development Program(R&D, P0010100)” supervised by the Korea Institute for Advancement of Technology(KIAT)