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Cutaneous microvessel circulation and vasomotion responses to local skin heating in women with HIV.
Author(s) -
Wang Dan,
Ma Yuchi,
Guendsechadze Shirin Claudia Nouri,
Yang Xiaoru,
Sun Philena,
Kalakurthy Samantha,
Carter Gabriela H.,
Kummar Princy,
Kassaye Seble,
Wilcox Christopher S.
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.09142
Subject(s) - vasomotion , medicine , laser doppler velocimetry , endothelial dysfunction , human immunodeficiency virus (hiv) , microcirculation , microvessel , blood flow , cardiology , immunology , angiogenesis
Background Patients infected with the human immunodeficiency virus (HIV) who are well treated by ART still suffer from many complications of microvascular dysfunction. Our previous ex vivo study reported that subcutaneous microvessels from women living with HIV had severe endothelial dysfunction. However, it is unknown whether the microvascular defect is more widespread. We tested the hypothesis that microvascular endothelial, neural and myogenic functions are impaired in women living with HIV compared to control women (control). Methods Women with HIV (n = 35) were compared to matched controls (n = 24). HIV infection was virally suppressed on antiretroviral therapy and both groups were enrolled in the DC Women’s Interagency HIV Study (DC – WIHS). Cutaneous blood flow (CBF) was measured by laser Doppler flowmetry (LDF) during an increase of local skin temperature from 33°C to 42°C. Vasomotion responses were analyzed using a wavelet transform to calculate the power of the frequency intervals associated with endothelial (0.0095 ‐0.012Hz), neural (0.021‐0.05Hz) and myogenic (0.051 ‐0.15Hz) activities of the Laser‐Doppler signal. Data are present as mean ± SEM. Result CBF was increased in both groups with LH at 42°C, but the increases of CBF to heat was lower in HIV infected women than controls (13.9 ± 1.1 vs 15.6 ± 1.2 fold, p<0.05). Vasomotion activities were similar between groups at baseline (33°C) and increased in both groups with LH at 42°C, but the increase was less in HIV compared to controls (13.9 ± 1.1 vs 15.6 ± 1.2 fold change, P <0.05). Moreover, compared to the control group, HIV had lower wavelet amplitude during LH in endothelial (100±3.8 vs 149± 15 PU/Hz/min, P<0.05), neural (92 ± 5 vs 132 ±15 PU/Hz/min, P<0.05) and myogenic (46±3 vs 60 ±7 PU/Hz/min, P=NS) frequency intervals. Conclusion Women living with HIV have impaired microvascular dysfunction with a complex derangement of microvascular circulatory regulation involving the endothelial, neural and myogenic components. Thus, fully preventing microvascular disease in HIV will require correction of widespread microvascular defects. Support or Funding Information National Heart, Lung, and Blood Institute (NHLBI), R01 HL134511