Premium
Effects of white adipose tissue denervation on cardiovascular and renal parameters in Wistar rats treated with high‐fat diet
Author(s) -
Nishi Erika E.,
Ferreira Giovanna R.,
Garcia Michele L.,
Campos Ruy R.,
Bergamaschi Cassia M. T.
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.08969
Subject(s) - medicine , endocrinology , baroreflex , white adipose tissue , adipose tissue , denervation , sympathetic nervous system , leptin , obesity , blood pressure , overweight , renin–angiotensin system , heart rate
Sympathetic nervous system and renin‐angiotensin‐aldosterone system overactivation plays a major role in cardiovascular changes in obesity. The white adipose tissue (WAT) is an essential endocrine organ that synthesizes several biologically active compounds that regulate metabolic homeostasis and contains both sensorial and sympathetic innervation. This study aimed to investigate the effects of retroperitoneal white adipose tissue (rWAT) denervation (DNX) on cardiovascular and renal parameters in obese rats. Animals were treated with a high‐fat diet (HFD) for 8 weeks to induce obesity and underwent surgical DNX procedure at 6 weeks. At the end of the experimental protocol, animals treated with HFD were significantly overweight, whereas the HFD+DNX group had a slightly decrease in body weight. The HFD group presented a discrete increase in baseline mean arterial pressure, which was normalized after DNX. Moreover, DNX improved bradycardic response gain when cardiac baroreflex control was evaluated in the HFD group. No changes were found in renal parameters. However, it was found a significant decrease in circulating angiotensinogen and leptin after rWAT DNX. Therefore, these findings suggest that rWAT innervation has influence on cardiovascular changes found in obesity. Support or Funding Information CAPES, CNPq and FAPESP