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Neural‐Like Plasticity in Airway Epithelia
Author(s) -
Reznikov Leah R.,
Liao Yan-Shin,
Guevara Maria
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.07337
Subject(s) - mucus , sensitization , secretion , creb , neuroplasticity , airway , neurotransmitter , in vivo , microbiology and biotechnology , biology , secretagogue , neuroscience , stimulus (psychology) , endocrinology , medicine , central nervous system , biochemistry , psychology , anesthesia , transcription factor , ecology , gene , psychotherapist
Many cells exhibit plasticity. In neurons, plasticity is associated with learning and memory. Here we describe plasticity in epithelia similar to neurons. In neurons, a strong or repeated stimulus often results in enhanced release of neurotransmitters via a process known as sensitization. We discovered that intra‐airway acid challenge in pigs resulted in a sensitization‐like augmentation of mucus secretion in airway epithelia that persisted in vitro . Treating airway epithelia from normal pigs with neurotransmitter secretagogues in vitro also induced a long‐lasting augmentation of mucus secretion. Inhibition of protein synthesis or cAMP‐responsive element‐binding (CREB) protein, which are required for neuronal memory, prevented secretagogue‐mediated increases in mucus secretion in airway epithelia, whereas inhibition of CREB in vivo mitigated some features of acid‐induced sensitization. These observations suggest new properties of airway epithelia that require further characterization and might be of critical importance in airway health and disease. Support or Funding Information R01HL153730 and OT2OD023854