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Comparison between Supplementation and a Diet High in Vitamins A, C, E on Inflammation and Oxidative Stress in Patients with Cardiometabolic Risk
Author(s) -
Ortiz-Avila Omar,
Campos-Arroyo Ana Gabriela,
del Carmen López-Miranda María
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.07124
Subject(s) - medicine , dyslipidemia , obesity , metabolic syndrome , vitamin e , oxidative stress , population , vitamin d and neurology , insulin resistance , physiology , environmental health , biology , antioxidant , biochemistry
Cardiometabolic risk refers to interrelated traditional risk factors for metabolic syndrome such as dyslipidemia, hypertension, obesity, insulin resistance, and hyperglycemia as well as behavioral factors such as physical inactivity, smoking, and unhealthy eating patterns. Family history, age, sex, and race/ethnicity also contribute to cardiometabolic risk. Currently Mexico has presented an increase in cases of obesity, according to the OCDE, Mexico is the second country, after the United States, with higher degree of obesity in the adult population. Oxidative stress and inflammation play a central role in the onset and development of many of the diseases that appear in patients with cardiometabolic risk, due to this an alternative in the treatment would be the use of antioxidants such as vitamins A, C and E. High dietary intake of vitamin C, carotenoids, and vitamin E have been associated with reduced risk of cardiovascular disease, cancer, and mortality, but these associations have not shown conclusive results. In addition, there is controversy between whether it is better to supplement these vitamins or include them in diet foods. Therefore, the objective of this work was to compare the effect between foods and supplements with a high contribution of vitamin C, A and E on markers of inflammation and oxidative stress in patients with cardiometabolic risk. The sample selection is from voluntary subjects and consists of 30 people between 30 and 60 years of age who present cardiometabolic risk factors, which were divided into two groups, one received the vitamins in supplements and the other in the food of the diet for 90 days. At the beginning and the end of the treatment, anthropometric measurements, biochemical determinations such as glucose and lipid profile, as well as markers of inflammation (IL‐6 and TNF‐α) and oxidative stress (TBARS and Glutathione) were performed. On average the patients was 33.4 years old and they had a BMI of 34.5. Women had a waist circumference of 88 cm and 102 cm for men which most were obese. In addition, patients had impaired fasting glucose levels (105.4 mg/dL) and low HDL levels (Men: 31.3 mg/dL; Women: 42 mg/dL). As they were patients with cardiometabolic risk presented oxidative stress and inflammation. The consumption of supplements showed a greater effect in reducing these parameters since were higher doses that can’t be achieved with diet foods. The results indicate that consumption of vitamins A, C and E in patients with cardiometabolic risk is a tool that can complement the treatment of these patients because it helps reduce oxidative stress and inflammation due to its antioxidant effects. Support or Funding Information This project was sponsored by the Instituto de Investigaciones de la Universidad de Morelia S.C.