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No Sex Differences in Cerebral Blood Velocity Responses During Resistance Exercise
Author(s) -
Sherman Sara R.,
Rosenberg Alexander J.,
Schroeder Elizabeth C.,
Lefferts Wesley K.,
Lima Natalia S.,
Grigoriadis Georgios,
Baynard Tracy
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.06289
Subject(s) - blood pressure , medicine , middle cerebral artery , cerebral blood flow , cardiology , photoplethysmogram , cerebral perfusion pressure , hemodynamics , pulse pressure , transcranial doppler , diastole , blood flow , cerebral autoregulation , pulsatile flow , cerebral arteries , mean arterial pressure , heart rate , autoregulation , ischemia , filter (signal processing) , computer science , computer vision
The brain requires intricate regulation of blood flow to maintain adequate perfusion to the tissue. Resistance exercise (RE) causes large increases in mean arterial pressure that challenges the regulation of cerebral blood flow. It is unknown, however, if the sex differences in blood pressure regulation may alter how cerebral blood flow responds to the large increases in blood pressure induced during RE. Purpose To determine if the cerebral blood velocity response during an acute bout of RE differs by sex. Methods Twenty‐nine young, healthy adults (M/F: 17/12; 25 ± 5 yrs; 23.9 ± 3.3 kg/m 2 ) performed 3 sets of 10 repetitions maximal isokinetic knee flexion/extension exercise. Systolic (SBP), diastolic (DBP), and mean (MAP) arterial pressure were measured using finger photoplethysmography and used to calculate pulse pressure (PP). Transcranial Doppler ultrasound (2 MHz) was used to measure right middle cerebral artery mean blood velocity (MCAmv) and calculate pulsatility index ([MCA systolic ‐ MCA diastolic velocity]/MCAmv). Conductance was calculated as MCAmv/MAP. The last 30‐sec of a 10‐min baseline and last 10‐sec of the 3 rd RE set were averaged for analyses. Results Overall, females had higher MCAmv and conductance compared to males ( p <0.05). SBP, DBP, MAP, PP, MCAmv increased and conductance decreased similarly for males and females during RE ( p <0.05). Pulsatility index did not change during RE in either sex ( p >0.05). Conclusions The blood pressure and cerebral hemodynamic response during RE was not different between sexes. These data suggest sex may not effect cerebrovascular responses to a large increase in blood pressure incurred during maximal RE in young healthy adults.Blood pressure and cerebral blood velocity responses at baseline and during an acute bout of resistance exercise in young adults.Male (n= 17) Female (n= 12)p for InteractionBaseline Resistance Exercise Baseline Resistance ExerciseSBP (mmHg) * 124 ± 10 172 ± 18 123 ± 7 170 ± 27 0.92DBP (mmHg) * 73 ± 7 99 ± 10 74 ± 7 103 ± 17 0.58MAP (mmHg) * 93 ± 8 128 ± 13 96 ± 7 132 ± 10 0.80PP (mmHg) * 52 ± 7 72 ± 11 50 ± 6 67 ± 14 0.42MCA Mean Velocity (cm/sec) *, ‡ 55 ± 9 65 ± 12 70 ± 15 81 ± 30 0.89MCA Pulsatility Index 0.90 ± 0.16 0.82 ± 0.14 0.81 ± 0.15 0.82 ± 0.27 0.27Conductance (cm/sec/mmHg) *, ‡ 0.60 ± 0.09 0.51 ±0.10 0.74 ± 0.17 0.62 ± 0.24 0.39All data are presented mean ± standard deviation * Main effect for time ( p <0.05) ‡ Main effect for sex ( p <0.05)