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Characterization of CO 2 Expiration and its Relationship with Performance Fatigability in Adaptation to Chronic Exercise Perturbation
Author(s) -
Wooten Liana C.,
Neville Brian T.,
Chin Lisa M.K.,
Guccione Andrew A.,
Keyser Randall E.
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.06091
Subject(s) - zoology , cardiology , expiration , medicine , chemistry , physical therapy , respiratory system , biology
Purpose This study characterized components of carbon dioxide expiration (VCO 2 ) and their relationship with performance fatigability (PF) in adaptation to chronic exercise perturbation. Methods 20 healthy men (n=9, age=44.7±13.9 ) and women (n=11, age=50.3±11.1) completed peak cardiopulmonary exercise (CPET) and constant work rate tests (CWRT) on separate days before and after a vigorous, 4‐week aerobic exercise training (AET) regimen. Each test was followed by 10‐minutes of passive recovery and an endurance test at 70% of the peak watts attainted during the CPET. PF was indexed by the endurance test durations following both the peak CPET (End1) and CWRT (End2), peak CPET time (pk‐Time), and peak CPET watts (pk‐Watts). Metabolic indices were calculated as total VO 2 (tVO 2 ), total VCO 2 (tVCO 2 ), metabolic VCO 2 (m‐VCO 2 ), and non‐metabolic VCO 2 (nm‐VCO 2 ). Data were analyzed for significant (p<0.05) changes and determinant relationships using paired t‐tests, and Pearson coefficients of determination (r 2 ). Results Significant reductions (Table ) in PF measures along with significant increases in tVO 2 , tVCO 2 , and nm‐VCO 2 were observed after AET. A change in m‐VCO2 was not observed. End1 (s) End2 (s) pk‐Time (s) pk‐Watts tVO 2 (ml) tVCO 2 (ml) m‐VCO 2 (ml) nm‐VCO 2 (ml) 265±337 p<0.01* 321±392 p<0.01* 63±40 p<0.001* 24±19 p<0.001* 1127±1569 p<0.01* 1512±2225 p<0.01* 904±2255 p=0.089 608±666 p<0.001* nm‐VCO 2 was strongly determinant of performance fatigability (pk‐Time r 2 =0.858, pk‐Watts r 2 =0.832, end1 r 2 =0.533, end2 r 2 =0.682, p<0.001*). Conclusion The current study demonstrated significant increases in the buffering component of total carbon dioxide expiration but not in the component associated with energy repletion. The buffering component was directly associated with measures of performance, providing plausibility that the buffering component may be a determinant of performance fatigability.End1 (s) End2 (s) pk‐Time (s) pk‐Watts tVO 2 (ml) tVCO 2 (ml) m‐VCO 2 (ml) nm‐VCO 2 (ml)265±337 321±392 63±40 24±19 1127±1569 1512±2225 904±2255 608±666p<0.01* p<0.01* p<0.001* p<0.001* p<0.01* p<0.01* p=0.089 p<0.001*