Premium
Cognitive function and regional body water analysis across the lifespan
Author(s) -
Lee Jinhyun,
Dudley-Javoroski Shauna A.,
Dubey Olga,
McCue Patrick M.,
Johnson Kristin A.,
Petrie Michael Arlyn,
Shields Richard K.
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.05569
Subject(s) - cognition , body water , trunk , compartment (ship) , medicine , psychology , neuroscience , body weight , biology , ecology , oceanography , geology
Objective Cognition decline occurs with age and adversely influences quality of life. Recent work suggests that systemic inflammation increases with age and may be associated with homeostasis of body water compartment levels. The extent to which fluid cognition is influenced by age and body water compartment distribution has not been carefully explored. Bioimpedance algorithms now enable us to analyze regional anatomical body water and determine estimates of the intra‐cellular and extra‐cellular water content levels. The ratio of the extra‐cellular water (ECW) relative to the intra‐cellular water (ICW) may provide a non‐invasive method to estimate systemic inflammation and predict cognitive function. In this study, we aspired to understand how age and water content predict fluid cognitive function in humans. Purpose We determined the correlation between anatomical regions of the body for water content (ECW/ICW) and cognitive function as a function of age. Methods There were 101 participants (Male: 50, age<40: 62, age>40: 39, age mean:39.9±18.7). We used a bioimpedance analysis device (InBody S10), which can estimate six regional extracellular water (ECW) and intracellular water (ICW) readings. We calculate the ratio of ECW to ICW (ECW/ICW) for each of the six regions: left leg, left arm, right leg, right arm, trunk, and total. The NIH cognition toolbox Pattern Comparison Processing Speed (PCPS), Picture Sequence Memory (PSM), Dimensional Change Card Sort (DCCS), FLANKER inhibitory control and attention (FLANKER) and List Sorting Working memory (LSW) were used to test cognitive function. The composite score was calculated from these five tests. Results The ECW/ICW of the left leg was significantly associated with all cognitive test results in the cohort with R‐squared values of 0.3, 0.46, 0.06, 0.12, 0.39, and 0.4 for FLANKER, LSW, PSM, PCPS, and the composite score, respectively. Age was highly correlated with cognitive test results in the cohort with R‐squared values of 0.32, 0.45, 0.07, 0.27, 0.5, 0.53, for the FLANKER, LSW, PSM, PCPS, and composite, respectively. FLANKER was highly correlated with bioimpedance indices in the older people with R‐squared values of 0.24, 0.22, 0.24, and 0.25 for the ECW/ICW total, ECW/ICW trunk, ECW/ICW right leg, and ECW/ICW left leg, respectively. FLANKER was not correlated with age in the older people with R‐squared value of 0.05. Conclusions The associations between cognitive function and bioimpedance indices were similar or higher than the associations between cognitive function and age. Future studies are needed to verify that ECW/ICW is associated with systemic inflammation and is a rigorous predictor of cognitive change, at any age. Support or Funding Information Research Support This study was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development: R01HD084645, R01HD082109